Topic: light-sheet microscope imaging

Navigation based on the formation, storage, and retrieval of spatial information is crucial for the survival of many species. We use a modification of a fully automated T-maze task for mice requiring flexible processing of visual information about the external environment. In our experimental design mice are presented with extra maze visual cues of different levels of complexity - general contexts and salient landmarks. They are conditioned to navigate based on the visual cues, acting against the spontaneous tendency to alternate. The animals are presented with pseudo-random sequences of turns