Uncovering transcriptome-wide lncRNA methylation and expression patterns in human glioma
Rugile Dragunaite, Giedrius Steponaitis, Rytis Stakaitis, Daina Skiriute · FENS Forum 2024
Alterations of N6-methyladenosine (m6A) RNA modifications are responsible for a platter of structural and functional changes in healthy and cancerous cell states. Even though several studies have linked m6A to the onset and development of tumors, very few have examined transcriptome-wide m6A landscape of long non-coding RNAs (lncRNAs) in cancerous cells, including gliomas. This work aims to explore and elucidate lncRNA m6A alterations and expression in glioma stem cells, U87-MG cells and glioma patients. We utilized four cell lines (NCH421k, NCH644, NCH690, U-87 MG), along with 16 glioblastoma
ePoster · Neuroscience