ePoster · Clinical Neurology
Novel potential biomarkers for multiple sclerosis: Evaluating the expression levels of miR-141, miR-9, MEG3, IFNG-AS1 and their relationship to different LINC00513 polymorphisms
Nada Sherif Amin, Yara Yasser, Mirna Ezzat, Mohamed Hamed, Ramez Reda Moustafa, Hend Mohamed Eltayebi · FENS Forum 2024
More pilot studies are emerging with the goal of contributing to the bigger puzzle of personalized multiple sclerosis (MS) therapies. This study aimed to examine the potential benefit of using four non-coding RNAs (ncRNAs) (miR-141, miR-9, MEG3, and IFNG-AS1) as prognostic and/or diagnostic biomarkers for MS. We also aimed to examine the relationship between two single nucleotide polymorphisms (SNPs), rs547311 and rs205764 on the long intergenic non-coding RNA (linc)-00513 gene (genotyping), and the expression levels of the aforementioned genes (qPCR), in addition to IFN-g (ELISA). The diagnos