The chromatin remodeler CHD7 acts as a chromatin hub coordinating differentiation of multiple cell lineages during hippocampal development
Yassin Harim, Chunxuan Shao, Heike Alter, Changwen Wang, Yue Zhuo, Gözde Bekki, Asya Sayin, Nadja Stöffler, Giulia Di Muzio, Katharina Hartmann, Anna Neuerburg, Pei-Chi Wei, Weijun Feng, Hai-Kun Liu · FENS Forum 2024
Chromatin remodelling plays an essential role in development, for instance by controlling gene expression during cell differentiation. Mutations of chromatin remodellers are often implicated in developmental diseases such as CHARGE syndrome, in which a heterozygous mutation of the chromatin remodeller CHD7 is the major driver of the disease. To investigate the role of Chd7 during brain development, we used a dorsal telencephalon-specific Chd7 loss-of-function mouse model and discovered Chd7 acts as a multi-lineage coordinator. Histological analysis of Chd7 mutant mice shows that upon ablation
ePoster · Neuroscience