Topic: LNX1

LNX1 and LNX2 proteins are closely related PDZ domain-containing E3 ubiquitin ligases expressed in neurons. They can interact with and potentially modulate a numerous synaptic proteins, but the in vivo physiological relevance of most of these interactions remains uncertain. We previously reported that mice lacking both LNX1 and LNX2 in the central nervous system exhibit decreased anxiety-related behaviour. Separately, abnormalities in social learning and sociability were described in a distinct LNX1 knockout mouse line. To extend this work we have examined: (1) anxiety-related behaviour in LNX