Long-term consequences of early life stress on noradrenergic neurons activation in male and female mice
Valentine Greffion, Déa Slavova, Maud Blaise, Stephanie de Gois, Bruno Giros, Elsa Isingrini · FENS Forum 2024
Major depression is a psychiatric disease extremely widespread and the leading cause of disability worldwide. Child abuse, defined as physical, emotional and/or sexual abuse or neglect, is considered as one of the strongest predictors of depression and suicidal behaviors. While the role of the locus-coeruleus noradrenergic system (LC-NE) in the long term effect of early life stress induced depression has been demonstrated in male, its involvement in female is lacking. The aim of this project is to better understand the contribution of LC-NE circuits in early life stress-induced depression in a
ePoster · Neuroscience