Topic: long-range connectivity

Mechanisms of top-down modulation in sensory perception and their relation to the underlying connectivity are not completely understood. Here we present a computational model of two interconnected cortical areas and use it to study the impact of inter-areal connectivity on sensory processing. The model integrates a multitude of data from rodent primary somatosensory cortex and reproduces biological features across multiple scales: from tens of ion channel models and electrical types, to thousands of morphologically detailed neurons, to millions of stochastic synapses mediating local and long-r