Sex-dependent BDNF-mediated effects of Fingolimod on the architecture of mouse hippocampal neurons
Aiswaria Lekshmi Kannan, Charlotte Tacke, Martin Korte, Marta Zagrebelsky · FENS Forum 2024
Brain derived neurotrophic factor (BDNF) plays a crucial role in regulating synaptic plasticity and neuronal architecture through complex downstream signalling cascades mediated via receptor Tyrosine Kinase B (TrkB). Impaired BDNF/TrkB signalling has been associated with several neurological disorders. A treatment with Fingolimod has been shown in vitro and in vivo to promote BDNF synthesis and release and exert BDNF-dependent neuroprotection. Estrogens are a group of steroid sex hormones synthesised by neurons and astrocytes predominantly in females. In the hippocampus, estradiol plays a cruc
ePoster · Neuroscience