Topic: low frequency EEG activity

Human invasive EEG recordings are used to guide clinical decision-making for epilepsy patients and offer an opportunity to better understand underlying neurophysiology. However, the relationship between macroscale electrophysiological recordings and underlying neural networks mechanisms remain unclear. Lundstrom et al [1,2] have shown that interictal (between-seizure) low frequency EEG activity (<1 Hz) is decreased at the seizure onset zone (SOZ), while higher frequency activity (1-50 Hz) is increased. These changes result in interictal power spectral densities (PSDs) with flattened slopes