Modulation of NREM sleep by corticotropin-releasing hormone through the thalamic reticular nucleus
Loredana Cumpana, Dinesh Kankanamge, Bryan Copits, Carmen Sandi, Simone Astori · FENS Forum 2024
The corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator in the central nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CRH modulates key TRN functions, such as sleep spindle rhythmogenesis, has not yet been explored.Using viral mapping, we identified diverse extra-hypothalamic CRH afferents to the TRN, such as the basolateral amygdala, zona incerta and subnuclei within the geniculate nucleus. Combining polysomnographic and photometric recordings in mice, we
ePoster · Neuroscience