Probes for the heterogeneity of muscimol binding sites in rat brain
Veronika Mueller, Margot Ernst, Aygul Baykuchkarova, Filip Koniuszewski, Konstantina Bampali, Thomas Seidel, Petra Scholze · FENS Forum 2024
Muscimol is a potent agonist of inhibitory GABAA-receptors, which are a heterogenous family of pentameric complexes. Muscimol is considered to bind to all receptor subtypes at the orthosteric β+/α- interface. In one of our recent publications, we observed that the antipsychotic drugs clozapine (CLZ), loxapine (LOX) and chlorpromazine (CPZ) showed diverging results in displacing 3H-muscimol. While a complete displacement could be observed by bicuculline (BIC), and no displacement with CPZ, the compounds CLZ and LOX could only incompletely compete with the radioligand. In addition, the dose-resp
ePoster · Neuroscience