Topic: Loxoribin

A growing body of evidence suggests a potential link between neuroinflammation, directly or indirectly triggered by viral infections, and the initiation or progression of neurodegenerative diseases such as Parkinson's disease (PD). Viral infections can potentially induce pathological alterations in amyloidogenic proteins such as a-synuclein (αSyn) implicated in pathogenesis of this disease. However, the exact molecular mechanisms of virus-induced neuroinflammation remain unclear.To get insights into mechanisms of viral RNA-induced neurotoxicity, we treated rat neuronal-glial co-cultures (CGC)