Alzheimer’s disease-associated Presenilin 2 influences the lipidic profile
Shirine Saleki, Loïc Quinton, Pascal Kienlen-Campard · FENS Forum 2024
Alzheimer's disease (AD), the most common neurodegenerative dementia, involves Presenilins (PS) 1 and 2, which are pivotal in amyloid-β (Aβ) production and amyloid pathology. PS functions, associated with inherited AD (FAD), extend beyond Aβ production. PS2 in particular is critical in mitochondrial function and cell bioenergetics. Here, we aim to explore Presenilins' role in cellular lipid metabolism.Brain samples were collected from WT, PS2 +/-, PS2 -/- and PS2N141I mice, carrying the FAD N141I mutation. We evaluated LPL and nSMase 2 levels based on preliminary data indicating their upregula
ePoster · Neuroscience