Topic: LRRTM4

Leucine rich repeat transmembrane proteins (LRRMTs) are synaptic adhesion proteins able to influence synapse development and function. LRRTM4, one of the 4 members of this protein group, is able to induce presynaptic differentiation and plays a significant role in excitatory synapse development. LRRTM4 polymorphisms have been linked to multiple neuropsychiatric diseases, but the underlying mechanisms are currently unclear. Therefore, we aimed to better understand the role of this gene for brain function by combining a battery of behavioural assays with transcriptomic and metabolomic analysis u