KIF5A, a protein involved in axonal transport, represents a new druggable target in a mouse model of spinal muscular atrophy
Valeria Valsecchi, Markella Baklou, Giusy Laudati, Xhesik Kolici, Paola Brancaccio, Giuseppe Pignataro · FENS Forum 2024
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by spinal cord and brainstem motor neuron (MN) loss. Axonal transport defects are a common hallmark of MN degeneration and KIF5A, a major component of the axonal transport machinery, has been associated with MN diseases, but its role in SMA has not been elucidated yet. Our aim was to investigate a possible correlation between KIF5A and SMA pathogenesis. Therefore, Western Blot, qRT-PCR and immunohistochemistry analysis were performed to investigate KIF5A and its adaptor protein complex Miro1/Milton expression in the spi
ePoster · Neuroscience