Topic: lumbar ventral horn

Despite the well-demonstrated modulatory effect of serotonin on spinal motor circuits, the specific roles and identity of the involved serotonergic neurons remain unclear. This ambiguity owes to the anatomical and neurochemical heterogeneity of the medullary brainstem regions housing the spinally-projecting serotonergic neurons, and to the limited number of studies investigating their connectivity and function cell-specifically.Here, we selectively target the midline serotonergic neurons of the caudal medulla (mCM-5HT) in the mouse to explore their output connectivity in the spinal cord and th