Central SELENOT expression regulates gonadotrope axis function, sexual behavior, and fertility in male and female mice
Ben Yamine Mallouki, Loubna Boukhzar, Ludovic Dumont, David Godefroy, Maria Manfredi-Lozano, Yves Tillet, Luca Grumolato, Nathalie Rives, Fatiha Chigr, Vincent Prévot, Youssef Anouar · FENS Forum 2024
Reproductive disorders are associated with neuroendocrine dysregulation in the hypothalamic-hypophysis-gonadal (HHG) axis, which can result from a defective production and action of the neuropeptide gonadotropin-releasing hormone (GnRH), the master regulator of reproduction. We have previously shown that SELENOT, a new thioredoxin-like selenoprotein highly expressed in endocrine and neuroendocrine cells, plays a role in hormone secretion. However, whether SELENOT is involved in neuroendocrine regulatory mechanisms that impinge on vital functions such as reproduction, is totally unknown. We fou
ePoster · Neuroscience