Meninges as an overlooked pharmacological target for globoid cell leukodystrophy
Alessia Amenta, Zulkifal Malik, Giulia Pruonto, Alessandra Ricca, Federica Cascino, Sissi Dolci, Francesca Ciarpella, Marco Riva, Ilaria Decimo, Angela Gritti, Francesco Bifari · FENS Forum 2024
Globoid cell Leukodystrophy Disease (GLD) is a neurodegenerative life-threatening disease caused by genetic defects in the lysosomal enzyme galactosylceramidase (GALC). There is no cure for GLD. Treatment options are still very poor. Here, we consider GLD pathogenesis from an entirely new angle, changing the focus from the neurons and oligodendrocytes to the non-parenchymal brain cells. Meninges host neural stem/precursor cells with neuronal differentiation potential and are emerging as injury-induced site in many neurodegenerative diseases. To study the involvement of meninges in GLD pathogen
ePoster · Neuroscience