Exploring neuroinflammatory signs in a zebrafish model of mucopolysaccharidosis type II: Early cues into pathogenic mechanisms
Maria Carla Macario, Rosa Manzoli, Lorenzo Badenetti, Enrico Moro · FENS Forum 2024
Mucopolysaccharidosis type II (MPS II) is a rare X-linked recessive lysosomal storage disease (LSD) caused by mutations of iduronate-2- sulfatase (IDS), a lysosomal enzyme involved in heparan and dermatan sulfate degradation. In pathological conditions, the abnormal storage of these molecules leads to a range of multisystemic symptoms affecting the central nervous system (CNS), which is extremely vulnerable to impaired lysosomal function. Indeed, LSDs neuropathological manifestations often involve microglial and astrocyte activation.In this context, I took advantage of an ids-mutant zebrafish
ePoster · Neuroscience