Modulatory effects of muscarinic M1 receptor agonist (VU0364572) in the cellular calcium and glutamate responses to cocaine in the mice nucleus accumbens and prefrontal cortex
Cesar Ramon Romero Leguizamon, Morgan Thomsen · FENS Forum 2024
In the characterization of cocaine addiction, various of its rewarding and reinforcing properties have been studied. Recently, in-vivo fiber photometry (FP) monitoring of calcium in the nucleus accumbens (NAc) and prefrontal cortex (PFC) have provide relevant information in the understanding of acute cocaine effects. In addition, another finding have reported the potential effect of the M1 receptor-selective agonist VU0364572 on the cessation of cocaine-seeking behavior. Here, we hypothesized that VU0364572 has some potential neuromodulator properties over the in-vivo dynamics of calcium and g
ePoster · Neuroscience