Phase-locked epidural electrical stimulation of the spinal cord in Parkinson's rat model
Elisa Garulli, Burce Kabaoglu, Rafael De Sa, Matthias Endres, Christoph Harms, Nikolaus Wenger · FENS Forum 2024
Epidural Electrical Stimulation (EES) of the spinal cord is a promising therapy that has alleviated gait deficits in animal models and patients with Parkinson's disease (PD). Here, we hypothesised that closed-loop stimulation - targeted to specific phases of cortical oscillations - can refine the interaction of EES with pathological network states. For this, we tailored a real-time system that tracks a selected frequency and used it to deliver stimulation pulses timed to ECOG signals from M2 cortex. We tested the stimulation platform in the unilateral 6-OHDA PD rat model, that resulted in modu
ePoster · Neuroscience