Presynaptic activity and muscle contraction regulate the cholinergic proteins involved in the ACh cycle through the action of muscarinic receptors in the skeletal muscle
Meryem Jami El Hirchi, Sofía Blasco Sebastián*, Aleksandra Polishchuk, Víctor Cilleros-Mañé, Marta Balanyà-Segura, Laia Just-Borràs, Erica Hurtado, Josep Tomàs, María Angel Lanuza · FENS Forum 2024
The neurotransmitter ACh plays a crucial role in the communication between motor neuron and muscle at the neuromuscular junction (NMJ). Synthesis, storage and degradation of ACh are performed by choline acetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT) and acetylcholinesterase (AChE), respectively. Presynaptic activity and nerve-induced muscle contraction regulate ACh release through muscarinic ACh autoreceptors (mAChRs). We previously identified a complex protein network including M1 and M2 mAChRs and multiple kinases that regulate ACh release at the NMJ. The aim of this w
ePoster · Neuroscience