Superior colliculus as a key player in Huntington’s disease sensorimotor coordination deficits: From circuits to behaviour
Melike Küçükerden, Sara Conde-Berriozabal, Laia Sitjà-Roqueta, Maryam Givehchi, Guadalupe Soria, Manuel Jose Rodríguez, Jordi Alberch, Mercè Masana · FENS Forum 2024
Huntington’s Disease (HD) is a neurodegenerative disorder characterised by severe motor disturbances resulting from neural network alterations, particularly evident in deficits in oculomotor functions during the prodromic stage. The superior colliculus (SC) plays a crucial role in integrating visual perception and oculomotor functions, and recent observations in the R6/1 HD mouse model from our group indicate affected connectivity between the M2 motor cortex (M2) and SC. To comprehensively assess changes in HD pathophysiology, we conducted fMRI-based functional connectivity analysis in 17-week
ePoster · Neuroscience