Cholinergic modulation of attentional performance on a signal detection task: Pharmacological modulation of nicotinic and muscarinic receptors
Harry Robson, Livia Wilod Versprille, Clara Velazquez-Sanchez, Matthew Bailey, Olivia Stupart, Johann du Hoffmann, Jeff Dalley · FENS Forum 2024
Cholinergic dysfunction contributes to attentional deficits in attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and dementia. Cortical cholinergic inputs are fundamentally linked to attention and phasic acetylcholine (Ach) release causally mediates performance in tasks involving monitoring for cues, cue detection, and cue-directed responding.We investigated the role of muscarinic and nicotinic ACh receptors (mAChRs and nAChRs) in attentional performance by applying systemic manipulations in adult male and female Sprague-Dawley rats during the Signal Detection Task. In this task,
ePoster · Neuroscience