Repetitive transcranial magnetic stimulation induced changes of N6-methyladenosine modified mRNAs
Elli-Anna Balta, Christos Galanis, Jakob Straehle, Michael Uhl, Matthias Kirsch, Rolf Backofen, Juergen Beck, Andreas Vlachos · FENS Forum 2024
Repetitive transcranial magnetic stimulation (rTMS) is a widely used method of non-invasive brain stimulation in both research and clinical settings, aimed at inducing synaptic plasticity and targeting conditions like pharmaco-resistant depression and post-traumatic stress disorder. However, the detailed molecular mechanisms underlying rTMS-induced plasticity remain not well understood. N6-methyladenosine (m6A) is the most prevalent modification in the human transcriptome. m6A is known for its reversible nature and thus is a prime candidate for modulating synaptic plasticity via gene expressio
ePoster · Neuroscience