Chromatin accessibility in oligodendrocyte precursors profiled by ATAC-seq: Neuroprotective effects of MgSO4 and 4-PBA alone or associated in a mouse model of encephalopathy of prematurity
Le Ray Marie-Anne, Lou Legouez, Anne Laure Schang, Jennifer Hua, Juliette Van Steenwinckle, Pierre Gressens, Stéphane Marret, Bruno J. Gonzalez, Clément Chollat, Carine Cleren · FENS Forum 2024
Cerebral palsy (CP) is the leading cause of motor disability in children. Hypoxia-ischemia (HI) and prematurity are main risk factors. Administration of magnesium sulfate (MgSO4) to mothers before 33 weeks' amenorrhea (SA) reduces the occurrence of CP at 2 years by around 30%. At this age, the white matter composed by oligodendrocytes, is particularly vulnerable. However, at long term, MgSO4 neuroprotective effects are not significant.Given the anti-inflammatory and antioxidant properties of 4-phenylbutyrate (4-PBA), its association with MgSO4 may optimize and prolong this neuroprotection in p
ePoster · Neuroscience