Topic: major depressive disorder (MDD)

Counterfactual information, or the mental representation of alternative outcomes, plays a critical role in value-based decision-making by allowing individuals to evaluate both chosen and unchosen options. Aberrant counterfactual processing is linked to psychiatric disorders like major depressive disorder (MDD). While the neural encoding of counterfactual outcomes is established, the mechanisms by which this feedback affects future decision-making are less clear. Using human intracranial electrophysiology, we show that counterfactual feedback influences subsequent choice behavior through beta o