Unravelling the contribution of GluA3 sub-unit to mouse behavior: From autoantibodies to gene depletion
Maria Italia, Federica Maltese, Elisa Zianni, Alessio Spinola, Elisa Di Lucia, Michela Salvadè, Diego Scheggia, Barbara Borroni, Monica Di Luca, Camilla Bellone, Fabrizio Gardoni · FENS Forum 2024
Traditionally, research on AMPA receptors has predominantly focused on GluA1 and GluA2 subunits. However, emerging consensus now emphasizes the pivotal role of GluA3 in specific forms of plasticity and behaviors. Though, most of the research conducted thus far has employed complete knockout animal model of GluA3-encoding gene (GRIA3) where compensatory events during neurodevelopment may obscure GluA3’s function.To better dissect GluA3's contribution to complex behaviors, we employed two in vivo mouse models of GluA3 downregulation in adult mice. First, we chronically administered autoantibodie
ePoster · Neuroscience