Topic: male mouse model

Anxiety disorders frequently accompanies aggression and their co-occurrence predicts worse functional impairment and poor prognosis. Nevertheless, the underlying neural mechanisms for co-occurring anxiety disorders and aggression remains elusive mostly due to the lack of appropriate animal models. Here, we designed a chronic coveted stress (CCS) male mouse model in which a pair of male mouse (owner) and a female mouse (partner) are physically separated from a peer conspecific male mouse (single) that poses a chronic emotional stress. After 7-day modeling, mice exposure to CCS exhibited anxiety