Gender-specific differences in cholinergic and GABA-ergic activity in the prefrontal cortex in prenatally valproic acid exposed adult rats
Maia Burjanadze, Nino Chkhvishvili, Gela Beselia · FENS Forum 2024
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral deficits. ASD is more common in males than in females; the neurobiological basis of the male prevalence remain poorly understood. The present study was designed to investigate gender specific differences in the expression level of the cholinergic (α7 nACh, M1) and GABA-ergic (γ-aminobutyric acid) alfa1 receptors in the medial prefrontal cortex (mPFC) in a rat model of autism. Experiments were carried out on prenatally VPA-treated and control (saline treated) adult (6 months) male and female rats. Immuno
ePoster · Neuroscience