Topic: malformations of cortical development

The cerebral cortex development is a process that involves the coordinated sequence of neural progenitor proliferation, neuronal differentiation and migration. Possible dysregulation of such processes results in malformations of cortical development (MCDs), such as periventricular heterotopias and polymicrogyria, which are characterized by morphological and functional cerebral complications. MCDs can be caused either by genetic or environmental factors. In this project, we selected to study a centriole and centriolar satellite gene, reported mutated in a patient with extensive polymicrogyria a