A novel microtubule doublet regulator in neuronal primary cilia
Juliette Wu, Dharshini Gopal, Jean-Christophe Deloulme, Manon de Andrade, Julie Delaroche, Laurence Serre, Eric Denarier, Annie Andrieux, Isabelle Arnal, Sylvie Gory-Fauré · FENS Forum 2024
Neurons are characterised by their intricate polarised morphology, crucial for proper CNS function. Achieving and maintaining this morphology is essential, facilitated by microtubules, key constituents of the neuronal cytoskeleton. Microtubule function is modulated by Microtubule Associated Proteins (MAPs), among which microtubule-stabilising MAP6d1 stands out for being the first neuronal protein identified to be directly involved in the formation of microtubule doublets in vitro. Microtubule doublets are highly stable structures specifically crucial for the formation and functioning of cilia
ePoster · Neuroscience