Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy
Francesca Giammello, Chiara Biella, Erica Cecilia Priori, Matilde Amat di San Filippo, Roberta Leone, Francesca D'Ambrosio, Martina Paterno', Giulia Cassioli, Cristina Spalletti, Ilaria Morella, Federica Barbieri, Giuseppe Lombardi, Tullio Florio, Riccardo Brambilla, Rossella Galli, Paola Rossi, Federico Brandalise · FENS Forum 2024
Glioblastoma multiforme (GBM) is a highly therapy-resistant primary brain tumor, especially due to the presence of Glioblastoma Stem Cells (GSCs). In fact, GBM treatment imposes a combination of brain surgery, radiotherapy and chemotherapy with Temozolomide (TMZ) but still fails to completely abolish the tumor. Given this, exploring differentiation induction in GSCs emerges as a promising strategy for GBM treatment. Accordingly, we aimed to investigate the mechanisms that regulate stemness maintenance and differentiation in GBM using Whole-Cell Patch Clamp, Western Blot, Immunofluorescence and
ePoster · Neuroscience