maskNMF: a denoise-sparsen-detect pipeline for demixing dense imaging data faster than real time
Amol Pasarkar, Liam Paninski, Pengcheng Zhou, Melissa Wu, Ian Kinsella, Daisong Pan, Jiang Lan Fan, Zhen Wang, Lamiae Abdeladim, Darcy Peterka, Hillel Adesnik, Na Ji · COSYNE 2023
In recent years, many calcium and voltage imaging methods have been developed in pursuit of a central goal of systems neuroscience: to study the function of large populations of neurons. Projective imaging methods, such as Bessel imaging, are a promising class of approaches in pursuit of this goal. These methods simultaneously record neural activity at a wide range of depths in the brain, effectively allowing scientists to image a volume of brain tissue. However, this added capability comes with a trade-off: all observed signals from the volume are projected onto a 2D imaging plane. Therefore,
Fri, Mar 10, 2023