Topic: MATCAP

Autophagy is a fundamental cellular process that plays a role in many physiological and pathophysiological processes. Microtubules are dynamic cytoskeletal fibers composed of tubulin dimers that have diverse structure and functions in cells. They are notably involved in cellular trafficking and autophagosome formation. The detyrosination/tyrosination cycle, a post-translational modification of tubulin, controls microtubule functions in healthy neurons, and its dysregulations lead to neuronal defects. This cycle is characterized by the enzymatic removal and re-addition of a gene-encoded tyrosin