Characterization of the transcriptional landscape of endogenous retroviruses at the fetal-maternal interface in a mouse model of autism spectrum disorder
Martina Giudice, Antonella Camaioni, Anna Maria Tartaglione, Vita Petrone, Claudia Matteucci, Gemma Calamandrei, Paola Sinibaldi-Vallebona, Laura Ricceri, Emanuela Balestrieri, Chiara Cipriani · FENS Forum 2024
Several adverse intrauterine conditions during pregnancy may increase the risk of neurodevelopmental disorders, including Autism Spectrum Disorder (ASD). Endogenous retroviruses (ERVs) have been proposed as co-factors in the pathogenesis of ASD, also potentially useful as early biomarkers of derailed neurodevelopment. Two preclinical models of ASD, the inbred BTBR T+tf/J (BTBR) mice, and mice prenatally exposed to valproic acid, showed an altered expression of several ERVs and cytokines, in embryos, blood and brain samples at different post-natal ages. The present study aimed to characterize t
ePoster · Neuroscience