Topic: maternal influenza infection

Maternal influenza infections pose a significant risk for neurodevelopmental disorders and have been linked to an increased incidence of autism and schizophrenia. While maternal immune activation is a well studied paradigm, most studies model only the acute stages due to use of synthetic viral mimetics. To investigate the impact of maternal influenza infection during pregnancy, we exposed pregnant mouse dams to influenza strains (dose of 1-3 LD50) with different virulence. Pregnant mice were exposed at different stages of gestation to understand whether cerebral cortical cell types showed diff