Functional and morphological alterations of parvalbumin-positive interneurons in the somatosensory cortex of mice in the early phase after traumatic brain injury
Qiang W, Werner Kilb, Thomas Mittmann · FENS Forum 2024
Traumatic Brain Injury (TBI) is known to impair motor coordination and affect cognitive functions. Parvalbumin-positive interneurons (PV-INs) are one subpopulation of GABAergic cells, which can balance their inhibitory output on connected pyramidal neurons, thereby influencing cortical network excitability. Here we investigated TBI-induced, morphological and functional changes of PV-Basket Cells (PV-BCs) in the ipsilateral hemisphere of somatosensory cortex and the underlying mechanisms. We used our established TBI model and performed immunohistochemistry, fluorescence in situ hybridization an
ePoster · Neuroscience