Assessment of adverse drug effects on cognitive function in cynomolgus macaques using an automated touchscreen-based CANTAB device
Sareer Ahmad, Daniela Smieja, Lars Mecklenburg · FENS Forum 2024
As part of the preclinical development for novel pharmaceuticals that target the Central Nervous System, regulatory authorities often request an assessment of potential adverse effects on cognitive function.In this study, we examined cognitive function in a group of eight naïve male cynomolgus monkeys using an automated touch screen device (mCANTAB). The aim was to assess its use under regulatory toxicity study conditions, and to characterize its performance in comparison to the Wisconsin General Test Apparatus methodology for object discrimination (Rose et al., 2015). Secondly, we investigate
ePoster · Neuroscience