Investigating how tanycytes integrate central thyroid hormone signals
Constance Kienle, Manon Rivagorda, Adriana Arrulo Pereira, Akila Chandrasekar, Sara Dori, Adrián Avellaneda Rodríguez, Frauke Spiecker, Helge Müller-Fielitz, Markus Schwaninger · FENS Forum 2024
The hypothalamus-pituitary-thyroid (HPT) axis is one of several hormone regulatory systems connecting the hypothalamus to its peripheral target organs and plays a fundamental role in maintaining the normal serum levels of circulating thyroid hormones (THs) and thus the euthyroid state. At the interface of the HPT - the third ventricle - reside the tanycytes, specialised ependymoglial cells. Their anatomical location allows tanycytes to act as gatekeepers of the HPT and regulate both the output of thyroid releasing hormone (TRH) and the entry of peripheral THs to the brain. Recently, it was sho
ePoster · Neuroscience