The bright side of mitochondrial calcium uniporter: MCU can protect hippocampal CA2 neurons from excitotoxic damage
Aleksandra Kaczynska, Malgorzata Beresewicz-Haller, Parisa Malakouti, Aleksandra Owczarek, Martyna Podgajna, Omar Basheer, Barbara Zablocka, Michal Wegrzynowicz · FENS Forum 2024
Mitochondrial calcium uniporter (MCU) is a protein that facilitates calcium ion influx into mitochondria. It is well established that MCU, through mitochondrial Ca2+ overload, may promote neuronal death in different neuropathological conditions, especially those involving excitotoxicity. Surprisingly, MCU distribution in hippocampus is inversely proportional to susceptibility of individual hippocampal subregions to death – the highest MCU expression is found in CA2, the lowest - in CA1 (the most and the least resistant regions, respectively). The aim of my study was therefore to assess cell ty
ePoster · Neuroscience