Topic: mechanosensitive ionic channel

In a recent study in rodents in our team, we showed that sonogenetic therapy can be applied to stimulate the visual cortex (V1) at a high spatiotemporal resolution with ultrasound following the expression of the MscL mechanosensitive ionic channel. Moreover, we proved that sonogenetic activation of V1 can generate visual perception using an associative learning test.To develop sonogenetics as a vision restoration therapy the next step is to prove visual perception via sonogenetic stimulation in non-human primates (NHPs).Methods: In consequence, we proceeded to obtain retinotopic maps of NHP’s