An ankyrin G binding motif mediates TRAAK localization to the axon initial segment
Virginia Luque Fernández, Arnaud Landra-Willm, Emil Arvedsen, Guillaume Sandoz, Hanne B. Rasmussen · FENS Forum 2024
The axon initial segment (AIS) is a critical compartment in neurons. It converts postsynaptic input into action potentials that trigger information transfer to target cells. This process relies on several voltage-gated sodium (Nav) and potassium (Kv) channels that accumulate in high densities at the AIS. Here, we identify the mechanosensitive potassium channel TRAAK (K2P4.1) as a component of the AIS in adult rat hippocampus and in cultured rat hippocampal neurons. We furthermore show that the AIS localization of TRAAK is driven by a C-terminal sequence that bears resemblance to ankyrin G bind
ePoster · Neuroscience