Medial anterior prefrontal cortex stimulation down-regulates implicit reactions to threats and prevents the return of fear
Eugenio Manassero, Giulia Concina, Maria Clarissa Chantal Caraig, Pietro Sarasso, Adriana Salatino, Raffaella Ricci, Benedetto Sacchetti · FENS Forum 2024
Down-regulating emotional overreactions toward threats is fundamental for developing treatments for anxiety and post-traumatic disorders. The prefrontal cortex (PFC) is critical for top-down modulatory processes, and despite previous studies adopting repetitive Transcranial Magnetic Stimulation (rTMS) over this region provided encouraging results in enhancing extinction, no studies have hitherto explored the effects of stimulating the medial anterior PFC (aPFC, encompassing the Brodmann area 10) on threat memory and generalization. In this study, we aimed to test an rTMS procedure over the aPF
ePoster · Neuroscience