Distinct hypothalamus-habenula circuits govern risk preference
Dominik Groos, Anna Maria Reuss, Peter Rupprecht, Tevye Stachniak, Shuting Han, Christopher Lewis, Adrian Roggenbach, Oliver Sturman, Yaroslav Sych, Martin Wieckhorst, Johannes Bohacek, Theofanis Karayannis, Adriano Aguzzi, Fritjof Helmchen · FENS Forum 2024
Appropriate risk evaluation is essential for survival in complex, uncertain environments. Confronted with choosing between certain (safe) and uncertain (risky) options, animals show strong preference for either option consistently across extended time periods. How such risk preference is encoded in the brain remains elusive. A candidate region is the lateral habenula (LHb), which is prominently involved in various value-guided behaviors. Here, using a balanced two-alternative choice task and longitudinal two-photon calcium imaging, we find LHb neurons with risk-preference-selective activity re
ePoster · Neuroscience