Cognitive and motor regulation by the novel Pthlh interneuron population in the mouse striatum
Monica Diez Salguero, Lisbeth Harder, Meritxell Llorca Torralba, Marla Herr, J. Manuel Barba Reyes, Esther Berrocoso, Jens Hjerling Leffler, Ana B. Muñoz Manchado · FENS Forum 2024
The neuronal population of the striatum is primarily composed of medium spiny projecting neurons (MSNs), with only a small percentage (around 5% in mice) being locally projecting neurons or interneurons. Despite their low numbers, interneurons play a crucial role in regulating the flow of information within the striatum and to other brain nuclei, thereby having significant implications for motor control and cognition.We recently identified one of the most abundant populations of GABAergic interneurons in the striatum that express Pthlh and varying levels of Pvalb, which correlates with intrins
ePoster · Neuroscience