Topic: Medulloblastoma

Medulloblastoma (MB) is an embryonal tumour that arises in the posterior fossa, being the most common malignant paediatric brain tumour. Currently there are four subgroups of medulloblastoma described, which arise from the alteration of specific neuronal stem or progenitor cell populations in exact spatio-temporal patterns(1). Group 4 MB (G4MB) is the most common subgroup of MB and has recently been described to arise from the failure of developmental processes in the differentiation of the rhombic lip (RL), implicating glutamatergic progenitors as putative cells of origin (2). Such cells orig