Multivariate pattern analysis on associations between resting-state whole-brain functional connectivity patterns and medial prefrontal GABA levels specific to major depressive disorder
Toshiki Iwabuchi, Yosuke Kameno, Masamichi Yokokura, Chihiro Murayama, Takafumi Goto, Taishi Tamayama, Tomoyasu Wakuda, Seico Benner, Yasuomi Ouchi, Hidenori Yamasue · FENS Forum 2024
Although the neurobiological mechanisms underlying major depressive disorder (MDD) are not fully understood, accumulating evidence suggests an association between MDD and reduced levels of gamma-aminobutyric acid (GABA) in the brain. The present study used proton magnetic resonance spectroscopy (1H-MRS) with the Mescher-Garwood point-resolved spectroscopy sequence (MEGA-PRESS) to measure GABA levels in the pregenual anterior cingulate cortex (pgACC)/medial prefrontal cortex (MPFC). We also assessed resting-state functional connectivity using functional magnetic resonance imaging (rs-fMRI). Ana
ePoster · Neuroscience