Impairment of AgRP neurons influences body weight, lifespan, and behavior in calorie-restricted mice
Eszter Balkó, Mátyás Kapiller, Boglárka Barsy, Ferenc Matyas, Peter Sotonyi, Tamas L. Horvath, Bence Racz · FENS Forum 2024
Hypothalamic agouti-related peptide (AgRP)-expressing neurons are exclusively located in the arcuate nucleus of the hypothalamus and form the basis of the melanocortin system, a set of CNS circuits regulating energy homeostasis. Besides an important role in driving food intake, AgRP neurons are also involved in modulating complex, non-feeding behaviors. However, it is unknown how AgRP-dependent feeding influences general exploratory behavior. Using the AgRPDTR mouse model with impaired AgRP neuronal functions, we show here that perturbation of AgRP neuronal function leads to sex-dependent body
ePoster · Neuroscience