Impact of Alzheimer’s disease on non-visual light perception, suprachiasmatic nucleus connectivity, and sleep regulation
Hugo Calligaro, Michael TY Lam, Brian Khov, Keun-Young Kim, Wonkyu K Ju, Mark H Ellisman, Satchidananda Panda · FENS Forum 2024
Circadian disruption, notably sleep disturbances, serves as an early indicator of Alzheimer’s disease (AD), preceding symptoms like memory loss. The suprachiasmatic nucleus (SCN) governs biological rhythms and receives direct retinal input via melanopsin-expressing retinal ganglion cells (mRGCs) to synchronize with environmental light cycles. The anatomical and functional basis for circadian disruption in AD remains unclear. Here, we explore the relationships between non-visual photoreception, SCN connectome evolution, and sleep regulation in the APP/PS1 mouse model.We measured mRGCs' light-in
ePoster · Neuroscience